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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.

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Title: Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Authors: Yurkovetskiy L; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; These authors contributed equally to this work., Wang X; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.; These authors contributed equally to this work., Pascal KE; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Tomkins-Tinch C; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA., Nyalile T; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Wang Y; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Baum A; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Diehl WE; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Dauphin A; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Carbone C; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Veinotte K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Egri SB; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Schaffner SF; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA., Lemieux JE; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114., Munro J; D epartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Rafique A; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Barve A; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands., Sabeti PC; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.; Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115 Boston, MA.; Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115., Kyratsous CA; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Dudkina N; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands., Shen K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jul 15. Date of Electronic Publication: 2020 Jul 15.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yurkovetskiy+L%22">Yurkovetskiy L</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.; These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Pascal+KE%22">Pascal KE</searchLink>; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591.<br /><searchLink fieldCode="AU" term="%22Tomkins-Tinch+C%22">Tomkins-Tinch C</searchLink>; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Nyalile+T%22">Nyalile T</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Baum+A%22">Baum A</searchLink>; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591.<br /><searchLink fieldCode="AU" term="%22Diehl+WE%22">Diehl WE</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Dauphin+A%22">Dauphin A</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Carbone+C%22">Carbone C</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Veinotte+K%22">Veinotte K</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Egri+SB%22">Egri SB</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Schaffner+SF%22">Schaffner SF</searchLink>; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Lemieux+JE%22">Lemieux JE</searchLink>; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.<br /><searchLink fieldCode="AU" term="%22Munro+J%22">Munro J</searchLink>; D epartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Rafique+A%22">Rafique A</searchLink>; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591.<br /><searchLink fieldCode="AU" term="%22Barve+A%22">Barve A</searchLink>; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sabeti+PC%22">Sabeti PC</searchLink>; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.; Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115 Boston, MA.; Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115.<br /><searchLink fieldCode="AU" term="%22Kyratsous+CA%22">Kyratsous CA</searchLink>; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591.<br /><searchLink fieldCode="AU" term="%22Dudkina+N%22">Dudkina N</searchLink>; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Shen+K%22">Shen K</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Luban+J%22">Luban J</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115.; Lead contact.
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