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Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.

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Title: Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.
Authors: Wilbs J; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Kong XD; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Middendorp SJ; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Prince R; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland., Cooke A; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA., Demarest CT; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA., Abdelhafez MM; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland., Roberts K; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA., Umei N; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA., Gonschorek P; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Lamers C; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Deyle K; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Rieben R; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland., Cook KE; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA., Angelillo-Scherrer A; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland., Heinis C; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland. christian.heinis@epfl.ch.
Source: Nature communications [Nat Commun] 2020 Aug 04; Vol. 11 (1), pp. 3890. Date of Electronic Publication: 2020 Aug 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.
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  Data: <searchLink fieldCode="AU" term="%22Wilbs+J%22">Wilbs J</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kong+XD%22">Kong XD</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Middendorp+SJ%22">Middendorp SJ</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Prince+R%22">Prince R</searchLink>; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cooke+A%22">Cooke A</searchLink>; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Demarest+CT%22">Demarest CT</searchLink>; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Abdelhafez+MM%22">Abdelhafez MM</searchLink>; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roberts+K%22">Roberts K</searchLink>; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Umei+N%22">Umei N</searchLink>; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Gonschorek+P%22">Gonschorek P</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lamers+C%22">Lamers C</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deyle+K%22">Deyle K</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rieben+R%22">Rieben R</searchLink>; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cook+KE%22">Cook KE</searchLink>; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Angelillo-Scherrer+A%22">Angelillo-Scherrer A</searchLink>; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Heinis+C%22">Heinis C</searchLink>; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland. christian.heinis@epfl.ch.
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