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PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance.

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Title: PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance.
Authors: Montaudon E; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Nikitorowicz-Buniak J; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Sourd L; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Morisset L; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., El Botty R; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Huguet L; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Dahmani A; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Painsec P; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Nemati F; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Vacher S; Department of Genetics, Institut Curie, Paris, France., Chemlali W; Department of Genetics, Institut Curie, Paris, France., Masliah-Planchon J; Department of Genetics, Institut Curie, Paris, France., Château-Joubert S; Alfort Veterinary School, 7 Av. Du Général-de-Gaulle, 94000, Maisons-Alfort, France., Rega C; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Leal MF; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Simigdala N; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Pancholi S; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Ribas R; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Nicolas A; Department of Pathology, Institut Curie, Paris, France., Meseure D; Department of Pathology, Institut Curie, Paris, France., Vincent-Salomon A; Department of Pathology, Institut Curie, Paris, France., Reyes C; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Rapinat A; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Gentien D; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France., Larcher T; INRA, APEX-PAnTher, Oniris, Rue De La Géraudière Cedex 3, 44322, Nantes, France., Bohec M; Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France., Baulande S; Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris, France., Bernard V; Department of Genetics, Institut Curie, Paris, France., Decaudin D; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France.; Department of Medical Oncology, Institut Curie, Paris, France., Coussy F; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France.; Department of Medical Oncology, Institut Curie, Paris, France., Le Romancer M; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 28 Rue Laennec, 69000, Lyon, France., Dutertre G; Department of Surgery, Institut Curie, Paris, France., Tariq Z; Department of Genetics, Institut Curie, Paris, France., Cottu P; Department of Medical Oncology, Institut Curie, Paris, France., Driouch K; Department of Genetics, Institut Curie, Paris, France., Bièche I; Department of Genetics, Institut Curie, Paris, France., Martin LA; Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK., Marangoni E; Translational Research Department, Institut Curie, 26 Rue d'Ulm, 75005, Paris, France. Elisabetta.marangoni@curie.fr.
Source: Nature communications [Nat Commun] 2020 Aug 13; Vol. 11 (1), pp. 4053. Date of Electronic Publication: 2020 Aug 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-020-17697-1