In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.
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| Title: | In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. |
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| Authors: | Turoňová B; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Sikora M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Schürmann C; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany., Hagen WJH; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany., Welsch S; Central Electron Microscopy Facility, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Blanc FEC; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., von Bülow S; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Gecht M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Bagola K; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany., Hörner C; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany., van Zandbergen G; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany., Landry J; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany., de Azevedo NTD; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany., Mosalaganti S; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Schwarz A; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany., Covino R; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany., Mühlebach MD; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany., Krijnse Locker J; Electron Microscopy of Pathogens Unit, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de., Beck M; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany. |
| Source: | Science (New York, N.Y.) [Science] 2020 Oct 09; Vol. 370 (6513), pp. 203-208. Date of Electronic Publication: 2020 Aug 18. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abd5223 |
