View in EDS HTML Full Text PDF Full Text

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.

Saved in:
Bibliographic Details
Title: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.
Authors: Turoňová B; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Sikora M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Schürmann C; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany., Hagen WJH; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany., Welsch S; Central Electron Microscopy Facility, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Blanc FEC; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., von Bülow S; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Gecht M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Bagola K; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany., Hörner C; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany., van Zandbergen G; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany., Landry J; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany., de Azevedo NTD; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany., Mosalaganti S; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany., Schwarz A; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany., Covino R; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany., Mühlebach MD; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany., Krijnse Locker J; Electron Microscopy of Pathogens Unit, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de., Beck M; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.
Source: Science (New York, N.Y.) [Science] 2020 Oct 09; Vol. 370 (6513), pp. 203-208. Date of Electronic Publication: 2020 Aug 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 32817270
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Turoňová+B%22">Turoňová B</searchLink>; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Sikora+M%22">Sikora M</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schürmann+C%22">Schürmann C</searchLink>; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Hagen+WJH%22">Hagen WJH</searchLink>; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Welsch+S%22">Welsch S</searchLink>; Central Electron Microscopy Facility, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Blanc+FEC%22">Blanc FEC</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bülow+S%22">von Bülow S</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Gecht+M%22">Gecht M</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Bagola+K%22">Bagola K</searchLink>; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Hörner+C%22">Hörner C</searchLink>; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany.<br /><searchLink fieldCode="AU" term="%22van+Zandbergen+G%22">van Zandbergen G</searchLink>; Division of Immunology, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; Institute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Landry+J%22">Landry J</searchLink>; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Azevedo+NTD%22">de Azevedo NTD</searchLink>; Genomics Core Facility, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mosalaganti+S%22">Mosalaganti S</searchLink>; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarz+A%22">Schwarz A</searchLink>; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Covino+R%22">Covino R</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Mühlebach+MD%22">Mühlebach MD</searchLink>; Division of Veterinary Medicine, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany.; German Center for Infection Research, Gießen-Marburg-Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Hummer+G%22">Hummer G</searchLink>; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Institute of Biophysics, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Krijnse+Locker+J%22">Krijnse Locker J</searchLink>; Electron Microscopy of Pathogens Unit, Paul Ehrlich Institute, Paul Ehrlich Strasse 51-59, 63225 Langen, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.<br /><searchLink fieldCode="AU" term="%22Beck+M%22">Beck M</searchLink>; Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, 69117 Heidelberg, Germany. gerhard.hummer@biophys.mpg.de jacomina.krijnselocker@pei.de martin.beck@biophys.mpg.de.; Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue Str. 3, 60438 Frankfurt am Main, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2020 Oct 09; Vol. 370 (6513), pp. 203-208. <i>Date of Electronic Publication: </i>2020 Aug 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32817270
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.abd5223
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 203
    Titles:
      – TitleFull: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Turoňová B
      – PersonEntity:
          Name:
            NameFull: Sikora M
      – PersonEntity:
          Name:
            NameFull: Schürmann C
      – PersonEntity:
          Name:
            NameFull: Hagen WJH
      – PersonEntity:
          Name:
            NameFull: Welsch S
      – PersonEntity:
          Name:
            NameFull: Blanc FEC
      – PersonEntity:
          Name:
            NameFull: von Bülow S
      – PersonEntity:
          Name:
            NameFull: Gecht M
      – PersonEntity:
          Name:
            NameFull: Bagola K
      – PersonEntity:
          Name:
            NameFull: Hörner C
      – PersonEntity:
          Name:
            NameFull: van Zandbergen G
      – PersonEntity:
          Name:
            NameFull: Landry J
      – PersonEntity:
          Name:
            NameFull: de Azevedo NTD
      – PersonEntity:
          Name:
            NameFull: Mosalaganti S
      – PersonEntity:
          Name:
            NameFull: Schwarz A
      – PersonEntity:
          Name:
            NameFull: Covino R
      – PersonEntity:
          Name:
            NameFull: Mühlebach MD
      – PersonEntity:
          Name:
            NameFull: Hummer G
      – PersonEntity:
          Name:
            NameFull: Krijnse Locker J
      – PersonEntity:
          Name:
            NameFull: Beck M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 10
              Text: 2020 Oct 09
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 370
            – Type: issue
              Value: 6513
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1