Succination inactivates gasdermin D and blocks pyroptosis.
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| Title: | Succination inactivates gasdermin D and blocks pyroptosis. |
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| Authors: | Humphries F; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Shmuel-Galia L; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Ketelut-Carneiro N; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Li S; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China., Wang B; Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, China., Nemmara VV; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA., Wilson R; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Jiang Z; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Khalighinejad F; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Muneeruddin K; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Shaffer SA; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Dutta R; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, OH 44106, USA., Ionete C; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Pesiridis S; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Yang S; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China., Thompson PR; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Fitzgerald KA; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu. |
| Source: | Science (New York, N.Y.) [Science] 2020 Sep 25; Vol. 369 (6511), pp. 1633-1637. Date of Electronic Publication: 2020 Aug 20. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abb9818 |
