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Succination inactivates gasdermin D and blocks pyroptosis.

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Title: Succination inactivates gasdermin D and blocks pyroptosis.
Authors: Humphries F; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Shmuel-Galia L; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Ketelut-Carneiro N; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Li S; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China., Wang B; Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, China., Nemmara VV; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA., Wilson R; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Jiang Z; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Khalighinejad F; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Muneeruddin K; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Shaffer SA; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Dutta R; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, OH 44106, USA., Ionete C; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Pesiridis S; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Yang S; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China., Thompson PR; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Fitzgerald KA; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu.
Source: Science (New York, N.Y.) [Science] 2020 Sep 25; Vol. 369 (6511), pp. 1633-1637. Date of Electronic Publication: 2020 Aug 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Succination inactivates gasdermin D and blocks pyroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Humphries+F%22">Humphries F</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Shmuel-Galia+L%22">Shmuel-Galia L</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Ketelut-Carneiro+N%22">Ketelut-Carneiro N</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Nemmara+VV%22">Nemmara VV</searchLink>; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Khalighinejad+F%22">Khalighinejad F</searchLink>; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Muneeruddin+K%22">Muneeruddin K</searchLink>; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Shaffer+SA%22">Shaffer SA</searchLink>; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+R%22">Dutta R</searchLink>; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Ionete+C%22">Ionete C</searchLink>; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Pesiridis+S%22">Pesiridis S</searchLink>; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Immunology, Key Laboratory of Immunological Environment and Disease, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Thompson+PR%22">Thompson PR</searchLink>; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+KA%22">Fitzgerald KA</searchLink>; Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2020 Sep 25; Vol. 369 (6511), pp. 1633-1637. <i>Date of Electronic Publication: </i>2020 Aug 20.
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