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Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.

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Title: Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Authors: Chin EN; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Yu C; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Vartabedian VF; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Jia Y; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Kumar M; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Gamo AM; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Vernier W; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Ali SH; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Kissai M; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Lazar DC; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Nguyen N; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Pereira LE; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Benish B; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Woods AK; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Joseph SB; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Chu A; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Johnson KA; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Sander PN; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Martínez-Peña F; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Hampton EN; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Young TS; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Chatterjee AK; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Schultz PG; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA., Petrassi HM; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu., Teijaro JR; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu., Lairson LL; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu.
Source: Science (New York, N.Y.) [Science] 2020 Aug 21; Vol. 369 (6506), pp. 993-999.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
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  Data: <searchLink fieldCode="AU" term="%22Chin+EN%22">Chin EN</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Vartabedian+VF%22">Vartabedian VF</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+M%22">Kumar M</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Gamo+AM%22">Gamo AM</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Vernier+W%22">Vernier W</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Ali+SH%22">Ali SH</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Kissai+M%22">Kissai M</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Lazar+DC%22">Lazar DC</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+LE%22">Pereira LE</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Benish+B%22">Benish B</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Woods+AK%22">Woods AK</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Joseph+SB%22">Joseph SB</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Chu+A%22">Chu A</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+KA%22">Johnson KA</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sander+PN%22">Sander PN</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Martínez-Peña+F%22">Martínez-Peña F</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Hampton+EN%22">Hampton EN</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Young+TS%22">Young TS</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wolan+DW%22">Wolan DW</searchLink>; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+AK%22">Chatterjee AK</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+PG%22">Schultz PG</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Petrassi+HM%22">Petrassi HM</searchLink>; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu.<br /><searchLink fieldCode="AU" term="%22Teijaro+JR%22">Teijaro JR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu.<br /><searchLink fieldCode="AU" term="%22Lairson+LL%22">Lairson LL</searchLink>; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. petrassi@scripps.edu jteijaro@scripps.edu llairson@scripps.edu.
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