Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.
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| Title: | Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. |
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| Authors: | Fahed AC; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Homburger JR; Color Genomics, Burlingame, CA, USA., Patel AP; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bick AG; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Neben CL; Color Genomics, Burlingame, CA, USA., Lai C; Color Genomics, Burlingame, CA, USA., Brockman D; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Philippakis A; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ellinor PT; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cassa CA; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lebo M; Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Boston, MA, USA., Ng K; Center for Computational Health, IBM Research, Cambridge, MA, USA., Lander ES; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Zhou AY; Color Genomics, Burlingame, CA, USA., Kathiresan S; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Verve Therapeutics, Cambridge, MA, USA., Khera AV; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. avkhera@mgh.harvard.edu.; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. avkhera@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. avkhera@mgh.harvard.edu.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. avkhera@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. avkhera@mgh.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2020 Aug 20; Vol. 11 (1), pp. 3635. Date of Electronic Publication: 2020 Aug 20. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-17374-3 |
