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Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

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Title: Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Authors: Klemm T; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Ebert G; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Calleja DJ; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Allison CC; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Richardson LW; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Bernardini JP; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories University of British Columbia, Vancouver, BC, Canada., Lu BG; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Kuchel NW; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Grohmann C; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Shibata Y; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Gan ZY; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Cooney JP; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Doerflinger M; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Au AE; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Blackmore TR; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., van der Heden van Noort GJ; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Geurink PP; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Ovaa H; Oncode Institute and Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Newman J; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Vic., Australia., Riboldi-Tunnicliffe A; Australian Synchrotron, ANSTO, Clayton, Vic., Australia., Czabotar PE; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Mitchell JP; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Lechtenberg BC; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Lowes KN; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Dewson G; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Pellegrini M; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia., Lessene G; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.; Pharmacology and Therapeutics Department, University of Melbourne, Melbourne, Vic., Australia., Komander D; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.
Source: The EMBO journal [EMBO J] 2020 Sep 15; Vol. 39 (18), pp. e106275. Date of Electronic Publication: 2020 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Klemm+T%22">Klemm T</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Ebert+G%22">Ebert G</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Calleja+DJ%22">Calleja DJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Allison+CC%22">Allison CC</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Richardson+LW%22">Richardson LW</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Bernardini+JP%22">Bernardini JP</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lu+BG%22">Lu BG</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Kuchel+NW%22">Kuchel NW</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Grohmann+C%22">Grohmann C</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Shibata+Y%22">Shibata Y</searchLink>; 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Australian Synchrotron, ANSTO, Clayton, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Czabotar+PE%22">Czabotar PE</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Mitchell+JP%22">Mitchell JP</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Feltham+R%22">Feltham R</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Lechtenberg+BC%22">Lechtenberg BC</searchLink>; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Vic., Australia.<br /><searchLink fieldCode="AU" term="%22Lowes+KN%22">Lowes KN</searchLink>; 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