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Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.

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Title: Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.
Authors: Overdijk MB; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Strumane K; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Beurskens FJ; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Ortiz Buijsse A; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Vermot-Desroches C; iDD biotech, Lyon, France., Vuillermoz BS; iDD biotech, Lyon, France., Kroes T; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., de Jong B; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Hoevenaars N; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Hibbert RG; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Lingnau A; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Forssmann U; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Schuurman J; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Parren PWHI; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands., de Jong RN; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton., Breij ECW; Genmab, Utrecht, the Netherlands, Copenhagen, Denmark, Princeton. ebj@genmab.com.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Oct; Vol. 19 (10), pp. 2126-2138. Date of Electronic Publication: 2020 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
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  Data: Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.
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              Text: 2020 Oct
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