Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
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| Title: | Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer. |
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| Authors: | Kho PF; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland, Australia., Amant F; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium., Annibali D; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium., Ashton K; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Centre for Information Based Medicine, University of Newcastle, Callaghan, New South Wales, Australia.; Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia., Attia J; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Auer PL; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Beckmann MW; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Black A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Brinton L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Buchanan DD; Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia., Chanock SJ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Chen C; Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Chen MM; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Cheng THT; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK., Cook LS; University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada., Crous-Bous M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., De Vivo I; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dowdy SC; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota, USA., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Dürst M; Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Ekici AB; Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA., Fridley BL; Department of Biostatistics, Kansas University Medical Center, Kansas City, Kansas, USA., Friedenreich CM; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada., García-Closas M; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Gaudet MM; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia, USA., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Goode EL; Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA., Gorman M; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology, Södersjukhuset, Stockholm, Sweden., Hankinson SE; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Biostatistics & Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA., Hein A; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Hillemanns P; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Hodgson S; Department of Clinical Genetics, St George's, University of London, London, UK., Hoivik EA; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway., Holliday EG; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Hunter DJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Jones A; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Krakstad C; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway., Lambrechts D; VIB Center for Cancer Biology, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Liang X; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Lissowska J; Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Lu L; Chronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA., Magliocco AM; Department of Anatomic Pathology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA., Martin L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., McEvoy M; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Milne RL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Mints M; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Nassir R; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA., Otton G; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Palles C; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK., Pooler L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Proietto T; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Rebbeck TR; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Renner SP; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Risch HA; Chronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA., Rübner M; Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Runnebaum I; Department of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany., Sacerdote C; Center for Cancer Prevention (CPO-Peimonte), Turin, Italy.; Human Genetics Foundation (HuGeF), Turin, Italy., Sarto GE; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA., Schumacher F; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Scott RJ; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.; Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia., Setiawan VW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Shah M; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Sheng X; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Southey MC; Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Tham E; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics, Karolinska Institutet, Stockholm, Sweden., Tomlinson I; Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Trovik J; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Tyrer JP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Van Den Berg D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Xia L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Xiang YB; State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Yang HP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Yu H; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Webb PM; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Spurdle AB; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Glubb DM; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., O'Mara TA; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Source: | International journal of cancer [Int J Cancer] 2021 Jan 15; Vol. 148 (2), pp. 307-319. Date of Electronic Publication: 2020 Aug 07. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1097-0215 |
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| DOI: | 10.1002/ijc.33206 |
