Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.

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Title: Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Authors: Lynch CJ; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Bernad R; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Martínez-Val A; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Shahbazi MN; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Biomedical Campus, Cambridge, UK., Nóbrega-Pereira S; Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Calvo I; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Blanco-Aparicio C; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Tarantino C; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Garreta E; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Richart-Ginés L; Maintenance of Transcriptional Repression by Polycomb Proteins, Institut Curie, Paris, France., Alcazar N; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Graña-Castro O; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Gómez-Lopez G; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Aksoy I; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France., Muñoz-Martín M; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Martinez S; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Ortega S; Transgenic Mice Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Prieto S; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Simboeck E; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Camasses A; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Stephan-Otto Attolini C; Bioinformatics-Biostatistics Unit, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Fernandez AF; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Sierra MI; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Fraga MF; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Pastor J; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Fisher D; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Montserrat N; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Savatier P; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France., Muñoz J; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Zernicka-Goetz M; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Division of Biology and Biological Engineering, Caltech, Pasadena, CA, USA., Serrano M; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. manuel.serrano@irbbarcelona.org.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. manuel.serrano@irbbarcelona.org.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. manuel.serrano@irbbarcelona.org.
Source: Nature cell biology [Nat Cell Biol] 2020 Oct; Vol. 22 (10), pp. 1223-1238. Date of Electronic Publication: 2020 Sep 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/s41556-020-0573-1