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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.

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Title: Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Authors: Lynch CJ; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Bernad R; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Martínez-Val A; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Shahbazi MN; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Biomedical Campus, Cambridge, UK., Nóbrega-Pereira S; Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Calvo I; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Blanco-Aparicio C; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Tarantino C; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Garreta E; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Richart-Ginés L; Maintenance of Transcriptional Repression by Polycomb Proteins, Institut Curie, Paris, France., Alcazar N; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Graña-Castro O; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Gómez-Lopez G; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Aksoy I; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France., Muñoz-Martín M; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Martinez S; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Ortega S; Transgenic Mice Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Prieto S; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Simboeck E; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Camasses A; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Stephan-Otto Attolini C; Bioinformatics-Biostatistics Unit, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Fernandez AF; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Sierra MI; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Fraga MF; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., Pastor J; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Fisher D; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France., Montserrat N; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Savatier P; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France., Muñoz J; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Zernicka-Goetz M; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Division of Biology and Biological Engineering, Caltech, Pasadena, CA, USA., Serrano M; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. manuel.serrano@irbbarcelona.org.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. manuel.serrano@irbbarcelona.org.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. manuel.serrano@irbbarcelona.org.
Source: Nature cell biology [Nat Cell Biol] 2020 Oct; Vol. 22 (10), pp. 1223-1238. Date of Electronic Publication: 2020 Sep 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
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  Data: <searchLink fieldCode="AU" term="%22Lynch+CJ%22">Lynch CJ</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bernad+R%22">Bernad R</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Val+A%22">Martínez-Val A</searchLink>; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Shahbazi+MN%22">Shahbazi MN</searchLink>; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; MRC Laboratory of Molecular Biology, Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Nóbrega-Pereira+S%22">Nóbrega-Pereira S</searchLink>; Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Calvo+I%22">Calvo I</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco-Aparicio+C%22">Blanco-Aparicio C</searchLink>; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tarantino+C%22">Tarantino C</searchLink>; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Garreta+E%22">Garreta E</searchLink>; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Richart-Ginés+L%22">Richart-Ginés L</searchLink>; Maintenance of Transcriptional Repression by Polycomb Proteins, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Alcazar+N%22">Alcazar N</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Graña-Castro+O%22">Graña-Castro O</searchLink>; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Lopez+G%22">Gómez-Lopez G</searchLink>; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Aksoy+I%22">Aksoy I</searchLink>; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France.<br /><searchLink fieldCode="AU" term="%22Muñoz-Martín+M%22">Muñoz-Martín M</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez+S%22">Martinez S</searchLink>; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ortega+S%22">Ortega S</searchLink>; Transgenic Mice Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Prieto+S%22">Prieto S</searchLink>; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Simboeck+E%22">Simboeck E</searchLink>; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Camasses+A%22">Camasses A</searchLink>; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Stephan-Otto+Attolini+C%22">Stephan-Otto Attolini C</searchLink>; Bioinformatics-Biostatistics Unit, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+AF%22">Fernandez AF</searchLink>; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Sierra+MI%22">Sierra MI</searchLink>; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Fraga+MF%22">Fraga MF</searchLink>; Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Institute of Oncology of Asturias (IUOPA), ISPA-Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor+J%22">Pastor J</searchLink>; Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fisher+D%22">Fisher D</searchLink>; IGMM, University of Montpellier, CNRS, Inserm, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Montserrat+N%22">Montserrat N</searchLink>; Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Savatier+P%22">Savatier P</searchLink>; Stem Cell and Brain Research Institute, Univ Lyon, Université Lyon 1, INSERM U1208, Bron, France.<br /><searchLink fieldCode="AU" term="%22Muñoz+J%22">Muñoz J</searchLink>; ProteoRed-ISCIII Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zernicka-Goetz+M%22">Zernicka-Goetz M</searchLink>; Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Division of Biology and Biological Engineering, Caltech, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+M%22">Serrano M</searchLink>; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. manuel.serrano@irbbarcelona.org.; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. manuel.serrano@irbbarcelona.org.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. manuel.serrano@irbbarcelona.org.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2020 Oct; Vol. 22 (10), pp. 1223-1238. <i>Date of Electronic Publication: </i>2020 Sep 28.
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