Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family.

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Title: Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family.
Authors: Peruzzo R; Department of Biology, University of Padua, Italy., Mattarei A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Italy., Azzolini M; Department of Biomedical Sciences, University of Padua, Italy., Becker-Flegler KA; Department of Molecular Biology, University of Duisburg-Essen, Germany., Romio M; Department of Chemical Sciences, University of Padua, Italy., Rigoni G; Department of Biology, University of Padua, Italy., Carrer A; Department of Biology, University of Padua, Italy; Department of Biomedical Sciences, University of Padua, Italy., Biasutto L; Department of Biomedical Sciences, University of Padua, Italy; CNR Institute of Neuroscience, Padua, Italy., Parrasia S; Department of Biomedical Sciences, University of Padua, Italy., Kadow S; Department of Molecular Biology, University of Duisburg-Essen, Germany., Managò A; Department of Biology, University of Padua, Italy., Urbani A; Department of Biology, University of Padua, Italy; Department of Biomedical Sciences, University of Padua, Italy., Rossa A; Department of Chemical Sciences, University of Padua, Italy., Semenzato G; Department of Medicine, University of Padua, Italy., Soriano ME; Department of Biology, University of Padua, Italy., Trentin L; Department of Medicine, University of Padua, Italy., Ahmad S; Department of Surgery, Medical School, University of Cincinnati, USA., Edwards M; Department of Surgery, Medical School, University of Cincinnati, USA., Gulbins E; Department of Molecular Biology, University of Duisburg-Essen, Germany., Paradisi C; Department of Chemical Sciences, University of Padua, Italy., Zoratti M; Department of Biomedical Sciences, University of Padua, Italy; CNR Institute of Neuroscience, Padua, Italy., Leanza L; Department of Biology, University of Padua, Italy., Szabò I; Department of Biology, University of Padua, Italy; CNR Institute of Neuroscience, Padua, Italy. Electronic address: ildiko.szabo@unipd.it.
Source: Redox biology [Redox Biol] 2020 Oct; Vol. 37, pp. 101705. Date of Electronic Publication: 2020 Sep 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2317
DOI:10.1016/j.redox.2020.101705