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Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

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Title: Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
Authors: Smith AL; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Whitehall JC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Bradshaw C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gay D; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Robertson F; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Blain AP; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hudson G; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Pyle A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Houghton D; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hunt M; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sampson JN; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Stamp C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mallett G; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Amarnath S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Wilson L; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Baker A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Russell OM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Johnson R; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Richardson CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gupta B; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McCallum I; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McDonald SA; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kelly S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mathers JC; Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH., Heer R; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Perkins ND; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Turnbull DM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sansom OJ; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Greaves LC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Source: Nature cancer [Nat Cancer] 2020 Oct; Vol. 1 (10), pp. 976-989. Date of Electronic Publication: 2020 Sep 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer
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  Data: Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Smith+AL%22">Smith AL</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Whitehall+JC%22">Whitehall JC</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Bradshaw+C%22">Bradshaw C</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Gay+D%22">Gay D</searchLink>; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. 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Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Russell+OM%22">Russell OM</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Johnson+R%22">Johnson R</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Richardson+CA%22">Richardson CA</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+B%22">Gupta B</searchLink>; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22McCallum+I%22">McCallum I</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22McDonald+SA%22">McDonald SA</searchLink>; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kelly+S%22">Kelly S</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Mathers+JC%22">Mathers JC</searchLink>; Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH.<br /><searchLink fieldCode="AU" term="%22Heer+R%22">Heer R</searchLink>; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK.<br /><searchLink fieldCode="AU" term="%22Taylor+RW%22">Taylor RW</searchLink>; 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