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Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.

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Title: Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.
Authors: Fondevila MF; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain., Mercado-Gómez M; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, and CIBER de Enfermedades Hepaticas y Digestivas (CIBERehd), Spain., Rodríguez A; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Gonzalez-Rellan MJ; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain., Iruzubieta P; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain., Valentí V; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Escalada J; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Schwaninger M; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Prevot V; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, European Genomic Institute for Diabetes (EGID), F-59000 Lille, France., Dieguez C; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain., Crespo J; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain., Frühbeck G; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain., Martinez-Chantar ML; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, and CIBER de Enfermedades Hepaticas y Digestivas (CIBERehd), Spain. Electronic address: mlmartinez@cicbiogune.es., Nogueiras R; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Galician Agency of Innovation (GAIN), Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
Source: Journal of hepatology [J Hepatol] 2021 Feb; Vol. 74 (2), pp. 469-471. Date of Electronic Publication: 2020 Oct 20.
Publication Type: Letter; Comment
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
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  Data: Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.
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  Data: <searchLink fieldCode="AU" term="%22Fondevila+MF%22">Fondevila MF</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain.<br /><searchLink fieldCode="AU" term="%22Mercado-Gómez+M%22">Mercado-Gómez M</searchLink>; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, and CIBER de Enfermedades Hepaticas y Digestivas (CIBERehd), Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+A%22">Rodríguez A</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain.<br /><searchLink fieldCode="AU" term="%22Iruzubieta+P%22">Iruzubieta P</searchLink>; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Valentí+V%22">Valentí V</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Escalada+J%22">Escalada J</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Schwaninger+M%22">Schwaninger M</searchLink>; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Prevot+V%22">Prevot V</searchLink>; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, European Genomic Institute for Diabetes (EGID), F-59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Dieguez+C%22">Dieguez C</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+J%22">Crespo J</searchLink>; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Research Institute Marqués de Valdecilla (IDIVAL), Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Frühbeck+G%22">Frühbeck G</searchLink>; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Obesity Area, Clínica Universidad de Navarra and IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Chantar+ML%22">Martinez-Chantar ML</searchLink>; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, and CIBER de Enfermedades Hepaticas y Digestivas (CIBERehd), Spain. Electronic address: mlmartinez@cicbiogune.es.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Galician Agency of Innovation (GAIN), Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2021 Feb; Vol. 74 (2), pp. 469-471. <i>Date of Electronic Publication: </i>2020 Oct 20.
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