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Identification of preferred multimodal ligand-binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations.

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Title: Identification of preferred multimodal ligand-binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations.
Authors: Gudhka RB; Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA., Bilodeau CL; Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA., McCallum SA; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA., McCoy MA; Biologics and Vaccines, Downstream Purification Development and Engineering, Merck & Co., Inc., Kenilworth, New Jersey, USA., Roush DJ; Biologics and Vaccines, Downstream Purification Development and Engineering, Merck & Co., Inc., Kenilworth, New Jersey, USA., Snyder MA; Process Chromatography Division, Bio-Rad Laboratories, Hercules, California, USA., Cramer SM; Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Source: Biotechnology and bioengineering [Biotechnol Bioeng] 2021 Feb; Vol. 118 (2), pp. 809-822. Date of Electronic Publication: 2020 Nov 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1097-0290
DOI:10.1002/bit.27611