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Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.

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Title: Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
Authors: Bakalov V; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Medicine Institute, Allegheny Health Network, Pittsburgh, PA, United States of America., Reyes-Uribe L; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America., Deshpande R; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America., Maloy AL; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America., Shapiro SD; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America., Angus DC; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America., Chang CH; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America., Le Moyec L; Université d'Evry Val d'Essonne-Université Paris-Saclay, Evry, France.; Muséum National d'Histoire Naturelle, Unité MCAM, UMR7245 CNRS, Paris, France., Wendell SG; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America., Kaynar AM; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
Source: PloS one [PLoS One] 2020 Nov 05; Vol. 15 (11), pp. e0241122. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Bakalov+V%22">Bakalov V</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Medicine Institute, Allegheny Health Network, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Reyes-Uribe+L%22">Reyes-Uribe L</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Deshpande+R%22">Deshpande R</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Maloy+AL%22">Maloy AL</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Shapiro+SD%22">Shapiro SD</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Angus+DC%22">Angus DC</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Chang+CH%22">Chang CH</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Le+Moyec+L%22">Le Moyec L</searchLink>; Université d'Evry Val d'Essonne-Université Paris-Saclay, Evry, France.; Muséum National d'Histoire Naturelle, Unité MCAM, UMR7245 CNRS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Wendell+SG%22">Wendell SG</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America.<br /><searchLink fieldCode="AU" term="%22Kaynar+AM%22">Kaynar AM</searchLink>; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
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