A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.

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Title: A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
Authors: Shin SH; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea., Kim HY; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea., Yoon HS; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea., Park WJ; Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea., Adams DR; School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK., Pyne NJ; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK., Pyne S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK., Park JW; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Source: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 08; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 08.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1422-0067
DOI:10.3390/ijms21218371