The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats.

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Title: The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats.
Authors: Darweesh RS; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan. rsdarweesh@just.edu.jo., El-Elimat T; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan., Zayed A; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan., Khamis TN; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan., Babaresh WM; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan., Arafat T; Jordan Center for Pharmaceutical Research (JCPR), Amman, 11195, Jordan., Al Sharie AH; Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Source: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2020 Nov 16; Vol. 21 (1), pp. 77. Date of Electronic Publication: 2020 Nov 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101590449 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-6511 (Electronic) Linking ISSN: 20506511 NLM ISO Abbreviation: BMC Pharmacol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2050-6511
DOI:10.1186/s40360-020-00456-9