Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma.

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Title: Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma.
Authors: Straathof K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Flutter B; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Wallace R; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Jain N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Loka T; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Depani S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Wright G; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Thomas S; UCL Cancer Institute, London WC1E 6DD, UK.; Autolus Ltd., London W12 7FP, UK., Cheung GW; UCL Cancer Institute, London WC1E 6DD, UK., Gileadi T; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Stafford S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Kokalaki E; UCL Cancer Institute, London WC1E 6DD, UK., Barton J; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK., Marriott C; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Ogunbiyi O; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Akarca AU; UCL Cancer Institute, London WC1E 6DD, UK., Marafioti T; UCL Cancer Institute, London WC1E 6DD, UK., Inglott S; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Gilmour K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Al-Hajj M; Autolus Ltd., London W12 7FP, UK., Day W; Autolus Ltd., London W12 7FP, UK., McHugh K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Biassoni L; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Sizer N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barton C; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Edwards D; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Dragoni I; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Silvester J; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Dyer K; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Traub S; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Elson L; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Brook S; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Westwood N; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Robson L; Centre for Drug Development, Cancer Research UK, London E20 1JQ, UK., Bedi A; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Howe K; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barry A; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Duncan C; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Barone G; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Pule M; UCL Cancer Institute, London WC1E 6DD, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk., Anderson J; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 1EH, UK. m.pule@ucl.ac.uk j.anderson@ucl.ac.uk.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
Source: Science translational medicine [Sci Transl Med] 2020 Nov 25; Vol. 12 (571).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abd6169