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Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.

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Title: Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
Authors: Patutina OA; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Gaponova Miroshnichenko SK; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Sen'kova AV; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Savin IA; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Gladkikh DV; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Burakova EA; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Fokina AA; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Maslov MA; Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry Named after N. A. Preobrazhensky, Moscow Institute of Radio Engineering, Electronics and Automation-Russian Technological University, 119454 Moscow, Russia., Shmendel' EV; Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry Named after N. A. Preobrazhensky, Moscow Institute of Radio Engineering, Electronics and Automation-Russian Technological University, 119454 Moscow, Russia., Wood MJA; Department of Paediatrics, University of Oxford, OX3 9DU Oxford, United Kingdom., Vlassov VV; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Altman S; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103; sidney.altman@yale.edu marzen@niboch.nsc.ru.; Life Sciences Division, Arizona State University, Tempe, AZ 85287-4501., Stetsenko DA; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Zenkova MA; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia; sidney.altman@yale.edu marzen@niboch.nsc.ru.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32370-32379. Date of Electronic Publication: 2020 Dec 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
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  Data: <searchLink fieldCode="AU" term="%22Patutina+OA%22">Patutina OA</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Gaponova+Miroshnichenko+SK%22">Gaponova Miroshnichenko SK</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Sen'kova+AV%22">Sen'kova AV</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Savin+IA%22">Savin IA</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Gladkikh+DV%22">Gladkikh DV</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Burakova+EA%22">Burakova EA</searchLink>; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Fokina+AA%22">Fokina AA</searchLink>; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Maslov+MA%22">Maslov MA</searchLink>; Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry Named after N. A. Preobrazhensky, Moscow Institute of Radio Engineering, Electronics and Automation-Russian Technological University, 119454 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Shmendel'+EV%22">Shmendel' EV</searchLink>; Department of Chemistry and Technology of Biologically Active Compounds, Medical and Organic Chemistry Named after N. A. Preobrazhensky, Moscow Institute of Radio Engineering, Electronics and Automation-Russian Technological University, 119454 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Wood+MJA%22">Wood MJA</searchLink>; Department of Paediatrics, University of Oxford, OX3 9DU Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vlassov+VV%22">Vlassov VV</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Altman+S%22">Altman S</searchLink>; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103; sidney.altman@yale.edu marzen@niboch.nsc.ru.; Life Sciences Division, Arizona State University, Tempe, AZ 85287-4501.<br /><searchLink fieldCode="AU" term="%22Stetsenko+DA%22">Stetsenko DA</searchLink>; Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.; Sector of Plant Chemical Biology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Zenkova+MA%22">Zenkova MA</searchLink>; Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia; sidney.altman@yale.edu marzen@niboch.nsc.ru.
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