Cerebral small vessel disease genomics and its implications across the lifespan.
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| Title: | Cerebral small vessel disease genomics and its implications across the lifespan. |
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| Authors: | Sargurupremraj M; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Suzuki H; Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo, Aoba, Sendai, 980-8573, Japan.; Department of Cardiovascular Medicine, Tohoku University Hospital, 1-1, Seiryo, Aoba, Sendai, 980-8574, Japan.; Department of Brain Sciences, Imperial College London, London, W12 0NN, UK., Jian X; University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, 78229, USA., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Evans TE; Department of Clinical Genetics, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA., Eiriksdottir G; Icelandic Heart Association, IS-201, Kópavogur, Iceland., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, 113-0033, Japan., Terzikhan N; Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Habes M; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, 78229, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2029, USA., Armstrong NJ; Mathematics and Statistics, Murdoch University, Murdoch, WA, 6150, Australia., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036, Graz, Austria., Yanek LR; GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK., Kumar RB; Department of Public Health Sciences, University of California at Davis, Davis, CA, 95616, USA., van den Akker EB; Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, 2333 ZA, Leiden, The Netherlands.; Pattern Recognition & Bioinformatics, Delft University of Technology, Delft, NL, 2629 HS, USA.; Leiden Computational Biology Centre, Leiden University Medical Centre, 2333 ZA, Leiden, The Netherlands., McWhirter RE; Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, TAS, 7005, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia., Trompet S; Department of Internal Medicine, section of gerontology and geriatrics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Mishra A; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Saba Y; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France.; Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, 78229, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, 02215, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA., Beaudet G; University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France., Petit L; University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France., Tsuchida A; University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France., Zago L; University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France., Schilling S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Sigurdsson S; Icelandic Heart Association, IS-201, Kópavogur, Iceland., Gottesman RF; Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lewis CE; University of Alabama at Birmingham School of Medicine, Birmingham, AL, 35233, USA., Aggarwal NT; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA., Lopez OL; Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2029, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Valdés Hernández MC; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.; Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, EH8 9JZ, UK., van der Grond J; Department of Radiology, Leiden University medical Center, 2333 ZA, Leiden, The Netherlands., Wright MJ; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, 4072, Australia., Knol MJ; Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, 17475, Greifswald, Germany., Thomson RJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.; Centre for Research in Mathematics and Data Science, Western Sydney University, Penrith, NSW, 2751, Australia., Bordes C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Le Grand Q; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Duperron MG; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Smith AV; Icelandic Heart Association, IS-201, Kópavogur, Iceland., Knopman DS; Mayo Clinic, Rochester, MN, 55905, USA., Schreiner PJ; University of Minnesota School of Public Health, Minneapolis, MN, 55455, USA., Evans DA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Beiser AS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, 02215, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA., Maniega SM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK., Beekman M; Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, 2333 ZA, Leiden, The Netherlands., Trollor J; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2052, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, 2052, Australia., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Vernooij MW; Department of Radiology & Nuclear Medicine, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Wittfeld K; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 17489, Greifswald, Germany., Niessen WJ; Department of Radiology & Nuclear Medicine, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.; Faculty of Applied Sciences, Delft University of Technology, Delft, NL, 2629 HS, USA., Soumaré A; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Boerwinkle E; University of Texas Health Science Center at Houston School of Public Health, Houston, TX, 77030, USA., Sidney S; Kaiser Permanente Division of Research, Oakland, CA, 94612, USA., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 55905, USA., Davies G; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036, Graz, Austria.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Thalamuthu A; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475, Greifswald, Germany., van Buchem MA; Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Bryan RN; The University of Texas at Austin Dell Medical School, Austin, TX, 78712, USA., Dupuis J; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, 78229, USA.; Department of Cardiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Bastin ME; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036, Graz, Austria.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Ames D; National Ageing Research Institute Royal Melbourne Hospital, Parkville, VIC, 3052, Australia.; Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, VIC, 3101, Australia., Teumer A; Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.; Department of Internal Medicine B, University Medicine Greifswald, 17475, Greifswald, Germany., Amouyel P; Inserm U1167, 59000, Lille, France.; Department of Epidemiology and Public Health, Pasteur Institute of Lille, 59000, Lille, France., Kwok JB; Brain and Mind Centre - The University of Sydney, Camperdown, NSW, 2050, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Bülow R; Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489, Greifswald, Germany., Deary IJ; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036, Graz, Austria.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Schofield PR; School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.; Neuroscience Research Australia, Randwick, NSW, 2031, Australia., Brodaty H; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, 2052, Australia., Jiang J; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Setoh K; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Miyamoto S; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Yoshida K; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Nagata M; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8501, Japan., Psaty BM; Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98195, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA.; Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Mosley TH; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Sachdev PS; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, 2031, Australia., Schmidt R; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2029, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, EC1M 6BQ, UK., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, SW7 2AZ, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Mpizani, 455 00, Greece., Trégouët DA; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France., Ikram MA; Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Wen W; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2052, Australia., DeCarli C; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, 95817, USA., Srikanth VK; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.; Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Jukema JW; Department of Cardiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Slagboom EP; Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, 2333 ZA, Leiden, The Netherlands., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2029, USA., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, 565-0871, Osaka, Japan., Mazoyer B; University of Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France., Wardlaw JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.; Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; MRC UK Dementia Research Institute at the University of Edinburgh, Edinburgh, EH8 9YL, UK., Nyquist PA; Department of Neurology, Johns Hopkins School of Medicine, Baltimone, MD, 21205, USA.; General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2052, Australia.; Neuroscience Research Australia, Randwick, NSW, 2031, Australia., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 17475, Greifswald, Germany., Schmidt H; Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria., Van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Gudnason V; Icelandic Heart Association, IS-201, Kópavogur, Iceland.; University of Iceland, Faculty of Medicine, 101, Reykjavík, Iceland., Longstreth WT Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, 98104-2420, USA., Launer LJ; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, 20892, USA.; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, 20892, USA., Lathrop M; University of McGill Genome Center, Montreal, QC, H3A 0G1, Canada., Seshadri S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, 78229, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, 02215, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA., Tzourio C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France.; CHU de Bordeaux, Pole de santé publique, Service d'information médicale, 33000, Bordeaux, France., Adams HH; Department of Clinical Genetics, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.; Department of Radiology & Nuclear Medicine, Erasmus MC, 3015 GE, Rotterdam, The Netherlands., Matthews PM; Department of Brain Sciences, Imperial College London, London, W12 0NN, UK.; UK Dementia Research Institute, London, WC1E 6BT, UK.; Data Science Institute, Imperial College London, London, SW7 2AZ, UK., Fornage M; University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA. myriam.fornage@uth.tmc.edu., Debette S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, 33000, Bordeaux, France. stephanie.debette@u-bordeaux.fr.; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA. stephanie.debette@u-bordeaux.fr.; Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France. stephanie.debette@u-bordeaux.fr. |
| Corporate Authors: | International Network against Thrombosis (INVENT) Consortium, International Headache Genomics Consortium (IHGC) |
| Source: | Nature communications [Nat Commun] 2020 Dec 08; Vol. 11 (1), pp. 6285. Date of Electronic Publication: 2020 Dec 08. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-19111-2 |
