Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report.
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| Title: | Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report. |
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| Authors: | Buckland MS; Department of Clinical Immunology, Barts Health, London, UK. m.buckland@ucl.ac.uk.; UCL GOSH Institute of Child Health Division of Infection and Immunity, Section of Cellular and Molecular Immunology, London, UK. m.buckland@ucl.ac.uk., Galloway JB; Centre for Rheumatic Diseases, King's College London, London, UK., Fhogartaigh CN; Department of Infection, Barts Health NHS Trust, London, UK., Meredith L; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Provine NM; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Bloor S; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Ogbe A; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Zelek WM; Systems Immunity Institute and Dementia Research Institute, Cardiff University, Cardiff, UK., Smielewska A; Division of Virology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.; PHE - Public Health England Laboratory, Cambridge. Box 236, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK., Yakovleva A; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Mann T; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QW, UK., Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Turner L; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Mescia F; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Toonen EJM; R&D Department, Hycult Biotechnology, Frontstraat 2A, 5405 PB, Uden, The Netherlands., Hackstein CP; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Akther HD; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Vieira VA; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ceron-Gutierrez L; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK., Periselneris J; Respiratory Department, King's College Hospital NHS Foundation Trust, UK. Department of Clinical Virology, Addenbrookes, UK., Kiani-Alikhan S; Department of Clinical Immunology, Barts Health, London, UK., Grigoriadou S; Department of Clinical Immunology, Barts Health, London, UK., Vaghela D; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK., Lear SE; Department of Immunology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Török ME; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Department of Microbiology, Cambridge, UK., Hamilton WL; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Stockton J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Quick J; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Nelson P; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Hunter M; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Coulter TI; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Devlin L; Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.; Regional Immunology Service, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK., Bradley JR; NIHR BioResource and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Ouwehand WH; Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Estcourt L; NHS Blood and Transplant, Oxford, UK., Harvala H; NHS Blood and Transplant, London, UK., Roberts DJ; NHS Blood and Transplant, Oxford, UK.; Radcliffe Department of Medicine and BRC Haematology Theme, University of Oxford, John Radcliffe Hospital, Oxford, UK., Wilkinson IB; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Screaton N; Radiology, Papworth Hospital, Cambridge, UK., Loman N; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Doffinger R; Respiratory Department, King's College Hospital NHS Foundation Trust, UK. Department of Clinical Virology, Addenbrookes, UK., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Morgan BP; Systems Immunity Institute and Dementia Research Institute, Cardiff University, Cardiff, UK., Goodfellow IG; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Klenerman P; Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk.; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK. njm25@cam.ac.uk.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK. njm25@cam.ac.uk., Thaventhiran JED; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk.; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QW, UK. jedt2@cam.ac.uk.; Cancer Research UK Cambridge Institute, Cambridge Biomedical Campus, Cambridge, UK. jedt2@cam.ac.uk. |
| Corporate Authors: | CITIID-NIHR COVID-19 BioResource Collaboration, MRC-Toxicology Unit COVID-19 Consortium |
| Source: | Nature communications [Nat Commun] 2020 Dec 14; Vol. 11 (1), pp. 6385. Date of Electronic Publication: 2020 Dec 14. |
| Publication Type: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-19761-2 |
