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Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.

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Title: Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.
Authors: Wisdom AJ; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27708, USA., Mowery YM; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA. yvonne.mowery@duke.edu.; Duke Cancer Institute, Durham, NC, 27708, USA. yvonne.mowery@duke.edu., Hong CS; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27708, USA., Himes JE; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27708, USA., Nabet BY; Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA.; Department of Oncology Biomarker Development, Genentech, South San Francisco, CA, 94080, USA., Qin X; Duke Cancer Institute, Durham, NC, 27708, USA., Zhang D; Duke Cancer Institute, Durham, NC, 27708, USA., Chen L; Merck & Co., Inc, Kenilworth, NJ, 07033, USA., Fradin H; Duke Center for Genomic and Computational Biology, Durham, NC, 27708, USA., Patel R; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Bassil AM; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Muise ES; Merck & Co., Inc, Kenilworth, NJ, 07033, USA., King DA; Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA.; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, 94305, USA., Xu ES; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Carpenter DJ; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Kent CL; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Smythe KS; Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Williams NT; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Luo L; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Ma Y; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA., Alizadeh AA; Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA.; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, 94305, USA., Owzar K; Duke Cancer Institute, Durham, NC, 27708, USA.; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, 27710, USA., Diehn M; Stanford Cancer Institute, Stanford University, Stanford, CA, 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, 94305, USA.; Department of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA., Bradley T; Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.; Center for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, MO, 64108, USA., Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27708, USA. david.kirsch@duke.edu.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27708, USA. david.kirsch@duke.edu.; Duke Cancer Institute, Durham, NC, 27708, USA. david.kirsch@duke.edu.
Source: Nature communications [Nat Commun] 2020 Dec 17; Vol. 11 (1), pp. 6410. Date of Electronic Publication: 2020 Dec 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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