First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.

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Bibliographic Details
Title:	First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Authors:	Bakker C; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Tasker T; Sosei Heptares, Cambridge, UK., Liptrot J; Sosei Heptares, Cambridge, UK., Hart EP; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Klaassen ES; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Prins S; Centre for Human Drug Research (CDHR), Leiden, Netherlands., van der Doef TF; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Brown GA; OMass Therapeutics Ltd, Oxford, UK., Brown A; Sosei Heptares, Cambridge, UK., Congreve M; Sosei Heptares, Cambridge, UK., Weir M; Sosei Heptares, Cambridge, UK., Marshall FH; Merck Sharp & Dohme Limited, London, UK., Cross DM; Cross Pharma Consulting Limited, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research (CDHR), Leiden, Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Nathan PJ; Sosei Heptares, Cambridge, UK.; Department of Psychiatry, University of Cambridge, UK.; School of Psychological Sciences, Monash University, Australia.
Source:	British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Jul; Vol. 87 (7), pp. 2945-2955. Date of Electronic Publication: 2021 Feb 05.
Publication Type:	Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1365-2125
DOI:	10.1111/bcp.14710