First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
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| Title: | First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M |
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| Authors: | Bakker C; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Tasker T; Sosei Heptares, Cambridge, UK., Liptrot J; Sosei Heptares, Cambridge, UK., Hart EP; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Klaassen ES; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Prins S; Centre for Human Drug Research (CDHR), Leiden, Netherlands., van der Doef TF; Centre for Human Drug Research (CDHR), Leiden, Netherlands., Brown GA; OMass Therapeutics Ltd, Oxford, UK., Brown A; Sosei Heptares, Cambridge, UK., Congreve M; Sosei Heptares, Cambridge, UK., Weir M; Sosei Heptares, Cambridge, UK., Marshall FH; Merck Sharp & Dohme Limited, London, UK., Cross DM; Cross Pharma Consulting Limited, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research (CDHR), Leiden, Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Nathan PJ; Sosei Heptares, Cambridge, UK.; Department of Psychiatry, University of Cambridge, UK.; School of Psychological Sciences, Monash University, Australia. |
| Source: | British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Jul; Vol. 87 (7), pp. 2945-2955. Date of Electronic Publication: 2021 Feb 05. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 33351971 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M<subscript>1</subscript> -receptor partial agonist for the treatment of dementias. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bakker+C%22">Bakker C</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tasker+T%22">Tasker T</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Liptrot+J%22">Liptrot J</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hart+EP%22">Hart EP</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Klaassen+ES%22">Klaassen ES</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Prins+S%22">Prins S</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Doef+TF%22">van der Doef TF</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Brown+GA%22">Brown GA</searchLink>; OMass Therapeutics Ltd, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brown+A%22">Brown A</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Congreve+M%22">Congreve M</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Weir+M%22">Weir M</searchLink>; Sosei Heptares, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+FH%22">Marshall FH</searchLink>; Merck Sharp & Dohme Limited, London, UK.<br /><searchLink fieldCode="AU" term="%22Cross+DM%22">Cross DM</searchLink>; Cross Pharma Consulting Limited, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Groeneveld+GJ%22">Groeneveld GJ</searchLink>; Centre for Human Drug Research (CDHR), Leiden, Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nathan+PJ%22">Nathan PJ</searchLink>; Sosei Heptares, Cambridge, UK.; Department of Psychiatry, University of Cambridge, UK.; School of Psychological Sciences, Monash University, Australia. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2021 Jul; Vol. 87 (7), pp. 2945-2955. <i>Date of Electronic Publication: </i>2021 Feb 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7503323 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2125 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203065251%22">03065251 </searchLink><i>NLM ISO Abbreviation: </i>Br J Clin Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=33351971 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/bcp.14710 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2945 Titles: – TitleFull: First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bakker C – PersonEntity: Name: NameFull: Tasker T – PersonEntity: Name: NameFull: Liptrot J – PersonEntity: Name: NameFull: Hart EP – PersonEntity: Name: NameFull: Klaassen ES – PersonEntity: Name: NameFull: Prins S – PersonEntity: Name: NameFull: van der Doef TF – PersonEntity: Name: NameFull: Brown GA – PersonEntity: Name: NameFull: Brown A – PersonEntity: Name: NameFull: Congreve M – PersonEntity: Name: NameFull: Weir M – PersonEntity: Name: NameFull: Marshall FH – PersonEntity: Name: NameFull: Cross DM – PersonEntity: Name: NameFull: Groeneveld GJ – PersonEntity: Name: NameFull: Nathan PJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2021 Jul Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1365-2125 Numbering: – Type: volume Value: 87 – Type: issue Value: 7 Titles: – TitleFull: British journal of clinical pharmacology Type: main |
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