Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.

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Title: Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.
Authors: Fresquet V; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain. jamcliment@unav.es vfresquet@unav.es., Garcia-Barchino MJ; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Larrayoz M; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Celay J; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Vicente C; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Fernandez-Galilea M; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain.; Center for Nutrition Research and Department of Nutrition, Food Science and Physiology, University of Navarra, IDISNA, CIBEROBN, Pamplona, Spain., Larrayoz MJ; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Calasanz MJ; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Panizo C; Department of Hematology, Clinica Universidad de Navarra, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Junza A; Universitat Rovira i Virgili, Department of Electronic Engineering, IISPV, CIBERDEM, Tarragona, Spain., Han J; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China., Prior C; Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBEREHD, Pamplona, Spain., Fortes P; Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBEREHD, Pamplona, Spain., Pio R; Division of Solid Tumors, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Oyarzabal J; Division of Molecular Therapeutics, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona, Spain., Martinez-Baztan A; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Paiva B; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Moreno-Aliaga MJ; Center for Nutrition Research and Department of Nutrition, Food Science and Physiology, University of Navarra, IDISNA, CIBEROBN, Pamplona, Spain., Odero MD; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Agirre X; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Yanes O; Universitat Rovira i Virgili, Department of Electronic Engineering, IISPV, CIBERDEM, Tarragona, Spain., Prosper F; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain.; Department of Hematology, Clinica Universidad de Navarra, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain., Martinez-Climent JA; Division of Hematology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, CIBERONC, Pamplona, Spain. jamcliment@unav.es vfresquet@unav.es.
Source: Cancer discovery [Cancer Discov] 2021 May; Vol. 11 (5), pp. 1268-1285. Date of Electronic Publication: 2020 Dec 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-20-1065