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Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.

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Title: Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.
Authors: Hamilton JZ; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Pires TA; Department of Chemistry, University of Illinois at Urbana-Champaign, 505 South Mathews Ave., Urbana, IL, 61801, USA., Mitchell JA; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Cochran JH; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Emmerton KK; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Zaval M; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Stone IJ; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Anderson ME; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Jin S; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Waight AB; Protein Sciences, Discovery Biologics, Merck Research Laboratories, 213 E Grand Ave., South San Francisco, CA, 94080, USA., Lyon RP; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Senter PD; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Jeffrey SC; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA., Burke PJ; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.
Source: ChemMedChem [ChemMedChem] 2021 Apr 08; Vol. 16 (7), pp. 1077-1081. Date of Electronic Publication: 2021 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Improving Antibody-Tubulysin Conjugates through Linker Chemistry and Site-Specific Conjugation.
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  Data: <searchLink fieldCode="AU" term="%22Hamilton+JZ%22">Hamilton JZ</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Pires+TA%22">Pires TA</searchLink>; Department of Chemistry, University of Illinois at Urbana-Champaign, 505 South Mathews Ave., Urbana, IL, 61801, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+JA%22">Mitchell JA</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Cochran+JH%22">Cochran JH</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Emmerton+KK%22">Emmerton KK</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Zaval+M%22">Zaval M</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Stone+IJ%22">Stone IJ</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+ME%22">Anderson ME</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Jin+S%22">Jin S</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Waight+AB%22">Waight AB</searchLink>; Protein Sciences, Discovery Biologics, Merck Research Laboratories, 213 E Grand Ave., South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lyon+RP%22">Lyon RP</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Senter+PD%22">Senter PD</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Jeffrey+SC%22">Jeffrey SC</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.<br /><searchLink fieldCode="AU" term="%22Burke+PJ%22">Burke PJ</searchLink>; Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2021 Apr 08; Vol. 16 (7), pp. 1077-1081. <i>Date of Electronic Publication: </i>2021 Feb 12.
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