Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
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| Title: | Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. |
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| Authors: | Mehta AR; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Gregory JM; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; MRC Edinburgh Brain Bank, Academic Department of Neuropathology, University of Edinburgh, Edinburgh, UK.; Edinburgh Pathology, University of Edinburgh, Edinburgh, UK., Dando O; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Carter RN; University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Burr K; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Nanda J; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., Story D; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK., McDade K; MRC Edinburgh Brain Bank, Academic Department of Neuropathology, University of Edinburgh, Edinburgh, UK., Smith C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; MRC Edinburgh Brain Bank, Academic Department of Neuropathology, University of Edinburgh, Edinburgh, UK.; Edinburgh Pathology, University of Edinburgh, Edinburgh, UK., Morton NM; University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Mahad DJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK., Hardingham GE; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Chandran S; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. siddharthan.chandran@ed.ac.uk.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. siddharthan.chandran@ed.ac.uk.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK. siddharthan.chandran@ed.ac.uk.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK. siddharthan.chandran@ed.ac.uk.; Centre for Brain Development and Repair, inStem, Bangalore, India. siddharthan.chandran@ed.ac.uk., Selvaraj BT; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. bthangar@ed.ac.uk.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. bthangar@ed.ac.uk.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK. bthangar@ed.ac.uk.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK. bthangar@ed.ac.uk. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2021 Feb; Vol. 141 (2), pp. 257-279. Date of Electronic Publication: 2021 Jan 04. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0533 |
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| DOI: | 10.1007/s00401-020-02252-5 |
