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Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.

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Title: Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.
Authors: Miyashita SI; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA., Zhang J; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA., Zhang S; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA., Shoemaker CB; Department of Infectious Diseases and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA., Dong M; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA. min.dong@childrens.harvard.edu.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Jan 06; Vol. 13 (575).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.
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  Data: <searchLink fieldCode="AU" term="%22Miyashita+SI%22">Miyashita SI</searchLink>; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Shoemaker+CB%22">Shoemaker CB</searchLink>; Department of Infectious Diseases and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.<br /><searchLink fieldCode="AU" term="%22Dong+M%22">Dong M</searchLink>; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA. min.dong@childrens.harvard.edu.; Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2021 Jan 06; Vol. 13 (575).
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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        Value: 10.1126/scitranslmed.aaz4197
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        Text: English
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      – TitleFull: Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.
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              Text: 2021 Jan 06
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