Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy.

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Title: Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T-cell Engagers Generates Antitumor Immunity While Avoiding Anergy.
Authors: Kharkwal SS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York.; Elstar Therapeutics, Cambridge, Massachusetts., Johndrow CT; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York., Veerapen N; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom., Kharkwal H; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.; Department of Clinical Oncology, Montefiore Medical Centre, Bronx, New York., Saavedra-Avila NA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York., Carreño LJ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York.; Millennium Institute on Immunology and Immunotherapy, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Rothberg S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York., Zhang J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York., Garforth SJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York., Jervis PJ; Centre of Chemistry, University of Minho, Braga, Portugal., Zhang L; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China.; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Donda A; Department of Oncology and Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland., Besra AK; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom., Cox LR; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, United Kingdom., Almo SC; Elstar Therapeutics, Cambridge, Massachusetts., Howell A; Vaccinex Inc., Rochester, New York., Evans EE; Vaccinex Inc., Rochester, New York., Zauderer M; Vaccinex Inc., Rochester, New York., Besra GS; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom., Porcelli SA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York. steven.porcelli@einsteinmed.org.
Source: Cancer research [Cancer Res] 2021 Apr 01; Vol. 81 (7), pp. 1788-1801. Date of Electronic Publication: 2021 Jan 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-20-2219