Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
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| Title: | Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. |
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| Authors: | Rappazzo CG; Adimab, LLC, Lebanon, NH 03766, USA., Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kaku CI; Adimab, LLC, Lebanon, NH 03766, USA., Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Sakharkar M; Adimab, LLC, Lebanon, NH 03766, USA., Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Deveau LM; Adimab, LLC, Lebanon, NH 03766, USA., Yockachonis TJ; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA., Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA., Battles MB; Adimab, LLC, Lebanon, NH 03766, USA., O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA., Brown ME; Adimab, LLC, Lebanon, NH 03766, USA., Geoghegan JC; Adimab, LLC, Lebanon, NH 03766, USA., Belk J; Adimab, LLC, Lebanon, NH 03766, USA., Peng L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Hou Y; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Scobey TD; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA., Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gunn BM; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gralinski LE; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com., Walker LM; Adimab, LLC, Lebanon, NH 03766, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Adagio Therapeutics, Inc., Waltham, MA 02451, USA. |
| Source: | Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abf4830 |
