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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.

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Title: Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Authors: Rappazzo CG; Adimab, LLC, Lebanon, NH 03766, USA., Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kaku CI; Adimab, LLC, Lebanon, NH 03766, USA., Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Sakharkar M; Adimab, LLC, Lebanon, NH 03766, USA., Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Deveau LM; Adimab, LLC, Lebanon, NH 03766, USA., Yockachonis TJ; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA., Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA., Battles MB; Adimab, LLC, Lebanon, NH 03766, USA., O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA., Brown ME; Adimab, LLC, Lebanon, NH 03766, USA., Geoghegan JC; Adimab, LLC, Lebanon, NH 03766, USA., Belk J; Adimab, LLC, Lebanon, NH 03766, USA., Peng L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Hou Y; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Scobey TD; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA., Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gunn BM; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gralinski LE; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com., Walker LM; Adimab, LLC, Lebanon, NH 03766, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Adagio Therapeutics, Inc., Waltham, MA 02451, USA.
Source: Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
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  Data: <searchLink fieldCode="AU" term="%22Rappazzo+CG%22">Rappazzo CG</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Tse+LV%22">Tse LV</searchLink>; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Kaku+CI%22">Kaku CI</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Wrapp+D%22">Wrapp D</searchLink>; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.<br /><searchLink fieldCode="AU" term="%22Sakharkar+M%22">Sakharkar M</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Deveau+LM%22">Deveau LM</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Yockachonis+TJ%22">Yockachonis TJ</searchLink>; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+AS%22">Herbert AS</searchLink>; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.<br /><searchLink fieldCode="AU" term="%22Battles+MB%22">Battles MB</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+CM%22">O'Brien CM</searchLink>; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.<br /><searchLink fieldCode="AU" term="%22Brown+ME%22">Brown ME</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Geoghegan+JC%22">Geoghegan JC</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Belk+J%22">Belk J</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Scobey+TD%22">Scobey TD</searchLink>; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Nemazee+D%22">Nemazee D</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Dye+JM%22">Dye JM</searchLink>; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.<br /><searchLink fieldCode="AU" term="%22Voss+JE%22">Voss JE</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Gunn+BM%22">Gunn BM</searchLink>; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.<br /><searchLink fieldCode="AU" term="%22McLellan+JS%22">McLellan JS</searchLink>; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.<br /><searchLink fieldCode="AU" term="%22Baric+RS%22">Baric RS</searchLink>; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Gralinski+LE%22">Gralinski LE</searchLink>; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.<br /><searchLink fieldCode="AU" term="%22Walker+LM%22">Walker LM</searchLink>; Adimab, LLC, Lebanon, NH 03766, USA. rbaric@email.unc.edu lgralins@email.unc.edu laura.walker@adimab.com.; Adagio Therapeutics, Inc., Waltham, MA 02451, USA.
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