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Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.

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Title: Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
Authors: Gramatica A; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Schwarzer R; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Brantley W; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Varco-Merth B; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Sperber HS; Vitalant Research Institute, San Francisco, California, USA.; Free University of Berlin, Institute of Biochemistry, Berlin, Germany., Hull PA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA., Montano M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA., Migueles SA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Rosenthal D; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Hogan LE; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Johnson JR; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA., Packard TA; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA., Grimmett ZW; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA., Herzig E; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Besnard E; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA., Nekorchuk M; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Hsiao F; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Urology, University of California, San Francisco, San Francisco, California, USA., Deeks SG; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Snape M; AMO Pharma Ltd., London, United Kingdom., Kiernan B; AMO Pharma Ltd., London, United Kingdom., Roan NR; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Urology, University of California, San Francisco, San Francisco, California, USA., Lifson JD; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Estes JD; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Verdin E; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA., Krogan NJ; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA., Henrich TJ; Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Connors M; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Ott M; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA., Pillai SK; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.; Vitalant Research Institute, San Francisco, California, USA., Okoye AA; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA warner.greene@gladstone.ucsf.edu okoyea@ohsu.edu., Greene WC; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA warner.greene@gladstone.ucsf.edu okoyea@ohsu.edu.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
Source: Journal of virology [J Virol] 2021 Mar 25; Vol. 95 (8). Date of Electronic Publication: 2021 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
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  Data: <searchLink fieldCode="AU" term="%22Gramatica+A%22">Gramatica A</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Schwarzer+R%22">Schwarzer R</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Brantley+W%22">Brantley W</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Varco-Merth+B%22">Varco-Merth B</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Sperber+HS%22">Sperber HS</searchLink>; Vitalant Research Institute, San Francisco, California, USA.; Free University of Berlin, Institute of Biochemistry, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hull+PA%22">Hull PA</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Montano+M%22">Montano M</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Migueles+SA%22">Migueles SA</searchLink>; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rosenthal+D%22">Rosenthal D</searchLink>; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hogan+LE%22">Hogan LE</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+JR%22">Johnson JR</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Packard+TA%22">Packard TA</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Grimmett+ZW%22">Grimmett ZW</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Herzig+E%22">Herzig E</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Besnard+E%22">Besnard E</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Nekorchuk+M%22">Nekorchuk M</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Hsiao+F%22">Hsiao F</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Urology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Deeks+SG%22">Deeks SG</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Snape+M%22">Snape M</searchLink>; AMO Pharma Ltd., London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kiernan+B%22">Kiernan B</searchLink>; AMO Pharma Ltd., London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Roan+NR%22">Roan NR</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Urology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Lifson+JD%22">Lifson JD</searchLink>; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Estes+JD%22">Estes JD</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Picker+LJ%22">Picker LJ</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Verdin+E%22">Verdin E</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Krogan+NJ%22">Krogan NJ</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Henrich+TJ%22">Henrich TJ</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Connors+M%22">Connors M</searchLink>; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ott+M%22">Ott M</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Pillai+SK%22">Pillai SK</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.; Vitalant Research Institute, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Okoye+AA%22">Okoye AA</searchLink>; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA warner.greene@gladstone.ucsf.edu okoyea@ohsu.edu.<br /><searchLink fieldCode="AU" term="%22Greene+WC%22">Greene WC</searchLink>; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA warner.greene@gladstone.ucsf.edu okoyea@ohsu.edu.; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
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