Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
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| Title: | Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. |
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| Authors: | Vasquez G; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Freestone GC; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Wan WB; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Low A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., De Hoyos CL; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Yu J; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Prakash TP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Ǿstergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Liang XH; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Crooke ST; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Migawa MT; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA., Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 1828-1839. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkab047 |
