Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

Saved in:
Bibliographic Details
Title: Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Authors: Crespo-Garcia S; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Tsuruda PR; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA. Electronic address: pam.tsuruda@unitybiotechnology.com., Dejda A; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Ryan RD; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Fournier F; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Chaney SY; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Pilon F; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dogan T; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Cagnone G; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Patel P; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Buscarlet M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dasgupta S; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Girouard G; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Rao SR; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Wilson AM; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., O'Brien R; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Juneau R; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Guber V; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dubrac A; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Beausejour C; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Armstrong S; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Mallette FA; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Yohn CB; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Joyal JS; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Marquess D; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Beltran PJ; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Sapieha P; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada. Electronic address: mike.sapieha@umontreal.ca.
Source: Cell metabolism [Cell Metab] 2021 Apr 06; Vol. 33 (4), pp. 818-832.e7. Date of Electronic Publication: 2021 Feb 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1932-7420
DOI:10.1016/j.cmet.2021.01.011