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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.

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Title: Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Authors: Crespo-Garcia S; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Tsuruda PR; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA. Electronic address: pam.tsuruda@unitybiotechnology.com., Dejda A; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Ryan RD; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Fournier F; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Chaney SY; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Pilon F; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dogan T; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Cagnone G; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Patel P; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Buscarlet M; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dasgupta S; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Girouard G; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Rao SR; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Wilson AM; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., O'Brien R; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Juneau R; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Guber V; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Dubrac A; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Beausejour C; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Armstrong S; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Mallette FA; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada., Yohn CB; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Joyal JS; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada., Marquess D; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Beltran PJ; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA., Sapieha P; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada. Electronic address: mike.sapieha@umontreal.ca.
Source: Cell metabolism [Cell Metab] 2021 Apr 06; Vol. 33 (4), pp. 818-832.e7. Date of Electronic Publication: 2021 Feb 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Crespo-Garcia+S%22">Crespo-Garcia S</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Tsuruda+PR%22">Tsuruda PR</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA. Electronic address: pam.tsuruda@unitybiotechnology.com.<br /><searchLink fieldCode="AU" term="%22Dejda+A%22">Dejda A</searchLink>; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Ryan+RD%22">Ryan RD</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Fournier+F%22">Fournier F</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Chaney+SY%22">Chaney SY</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Pilon+F%22">Pilon F</searchLink>; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Dogan+T%22">Dogan T</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cagnone+G%22">Cagnone G</searchLink>; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Buscarlet+M%22">Buscarlet M</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Dasgupta+S%22">Dasgupta S</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Girouard+G%22">Girouard G</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Rao+SR%22">Rao SR</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+AM%22">Wilson AM</searchLink>; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22O'Brien+R%22">O'Brien R</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Juneau+R%22">Juneau R</searchLink>; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Guber+V%22">Guber V</searchLink>; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Dubrac+A%22">Dubrac A</searchLink>; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Beausejour+C%22">Beausejour C</searchLink>; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Armstrong+S%22">Armstrong S</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mallette+FA%22">Mallette FA</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada.<br /><searchLink fieldCode="AU" term="%22Yohn+CB%22">Yohn CB</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Joyal+JS%22">Joyal JS</searchLink>; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Marquess+D%22">Marquess D</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Beltran+PJ%22">Beltran PJ</searchLink>; UNITY Biotechnology, 285 E Grand Avenue, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Sapieha+P%22">Sapieha P</searchLink>; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal QC H1T 2M4, Canada. Electronic address: mike.sapieha@umontreal.ca.
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  Data: <searchLink fieldCode="JN" term="%22101233170%22">Cell metabolism</searchLink> [Cell Metab] 2021 Apr 06; Vol. 33 (4), pp. 818-832.e7. <i>Date of Electronic Publication: </i>2021 Feb 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101233170 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-7420 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215504131%22">15504131 </searchLink><i>NLM ISO Abbreviation: </i>Cell Metab <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.cmet.2021.01.011
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