CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model.

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Title: CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model.
Authors: Burrack AL; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Rollins MR; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Spartz EJ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Mesojednik TD; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Schmiechen ZC; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Raynor JF; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Wang IX; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415., Kedl RM; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Center, Aurora, CO 80045., Stromnes IM; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55414; ingunn@umn.edu.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55415.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55414; and.; Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, MN 55414.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Mar 15; Vol. 206 (6), pp. 1372-1384. Date of Electronic Publication: 2021 Feb 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-6606
DOI:10.4049/jimmunol.2000765