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Radiolabelling and preclinical characterization of 89Zr-Df-radiolabelled bispecific anti-PD-L1/TGF-βRII fusion protein bintrafusp alfa.

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Title: Radiolabelling and preclinical characterization of 89Zr-Df-radiolabelled bispecific anti-PD-L1/TGF-βRII fusion protein bintrafusp alfa.
Authors: Burvenich IJG; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Goh YW; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia., Guo N; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia., Gan HK; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Rigopoulos A; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Cao D; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Liu Z; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Ackermann U; School of Cancer Medicine, La Trobe University, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia., Wichmann CW; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., McDonald AF; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Huynh N; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia., O'Keefe GJ; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia., Gong SJ; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; School of Engineering and Mathematical Sciences, La Trobe University, Melbourne, Australia., Scott FE; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia., Li L; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA., Geng W; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA., Zutshi A; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA., Lan Y; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA., Scott AM; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia. andrew.scott@onjcri.org.au.; School of Cancer Medicine, La Trobe University, Melbourne, Australia. andrew.scott@onjcri.org.au.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia. andrew.scott@onjcri.org.au.; Department of Medicine, University of Melbourne, Melbourne, Australia. andrew.scott@onjcri.org.au.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Sep; Vol. 48 (10), pp. 3075-3088. Date of Electronic Publication: 2021 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
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  Data: Radiolabelling and preclinical characterization of <superscript>89</superscript>Zr-Df-radiolabelled bispecific anti-PD-L1/TGF-βRII fusion protein bintrafusp alfa.
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  Data: <searchLink fieldCode="AU" term="%22Burvenich+IJG%22">Burvenich IJG</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Goh+YW%22">Goh YW</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22Guo+N%22">Guo N</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22Gan+HK%22">Gan HK</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Rigopoulos+A%22">Rigopoulos A</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Cao+D%22">Cao D</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Ackermann+U%22">Ackermann U</searchLink>; School of Cancer Medicine, La Trobe University, Melbourne, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Wichmann+CW%22">Wichmann CW</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22McDonald+AF%22">McDonald AF</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Huynh+N%22">Huynh N</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.<br /><searchLink fieldCode="AU" term="%22O'Keefe+GJ%22">O'Keefe GJ</searchLink>; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; Department of Medicine, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Gong+SJ%22">Gong SJ</searchLink>; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.; School of Engineering and Mathematical Sciences, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Scott+FE%22">Scott FE</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Geng+W%22">Geng W</searchLink>; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zutshi+A%22">Zutshi A</searchLink>; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lan+Y%22">Lan Y</searchLink>; EMD Serono Research & Development Institute, Inc., a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scott+AM%22">Scott AM</searchLink>; Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia. andrew.scott@onjcri.org.au.; School of Cancer Medicine, La Trobe University, Melbourne, Australia. andrew.scott@onjcri.org.au.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia. andrew.scott@onjcri.org.au.; Department of Medicine, University of Melbourne, Melbourne, Australia. andrew.scott@onjcri.org.au.
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