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Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial.

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Title: Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial.
Authors: Larson RA; Department of Medicine and Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA. rlarson@medicine.bsd.uchicgo.edu., Mandrekar SJ; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA., Huebner LJ; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA., Sanford BL; Alliance Statistics and Data Center, Duke University, Durham, NC, USA., Laumann K; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA., Geyer S; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA., Bloomfield CD; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Thiede C; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany., Prior TW; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Döhner K; Department of Internal Medicine III, University of Ulm, Ulm, Germany., Marcucci G; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Voso MT; Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy., Klisovic RB; Emory University School of Medicine, Atlanta, GA, USA., Galinsky I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wei AH; Department of Clinical Haematology, The Alfred Hospital and Monash University, Melbourne, Australia., Sierra J; Hematology Department, Hospital de la Santa Creu i Sant Pau, IIB Sant Pau and Jose Carreras Leukemia Research Institute, Autonomous University of Barcelona, Barcelona, Spain., Sanz MA; Department of Hematology, Hospital Universitario y Politécnico La Fe and Department of Medicine, University of Valencia, Valencia, Spain., Brandwein JM; Department of Medicine, University of Alberta, Edmonton, AB, Canada., de Witte T; Radboud University Medical Centre, Nijmegen, Netherlands., Niederwieser D; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany., Appelbaum FR; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Medeiros BC; Division of Hematology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA, USA., Tallman MS; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Krauter J; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Schlenk RF; Department of Internal Medicine III, University of Ulm, Ulm, Germany.; NCT Trial Center, National Center of Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany., Ganser A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Serve H; Department of Medicine II, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt/Main, Germany., Ehninger G; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany., Amadori S; Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy., Gathmann I; Novartis Pharma AG, Basel, Switzerland., Döhner H; Department of Internal Medicine III, University of Ulm, Ulm, Germany., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Source: Leukemia [Leukemia] 2021 Sep; Vol. 35 (9), pp. 2539-2551. Date of Electronic Publication: 2021 Mar 02.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial.
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  Data: <searchLink fieldCode="AU" term="%22Larson+RA%22">Larson RA</searchLink>; Department of Medicine and Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA. rlarson@medicine.bsd.uchicgo.edu.<br /><searchLink fieldCode="AU" term="%22Mandrekar+SJ%22">Mandrekar SJ</searchLink>; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Huebner+LJ%22">Huebner LJ</searchLink>; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sanford+BL%22">Sanford BL</searchLink>; Alliance Statistics and Data Center, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Laumann+K%22">Laumann K</searchLink>; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Geyer+S%22">Geyer S</searchLink>; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Bloomfield+CD%22">Bloomfield CD</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Thiede+C%22">Thiede C</searchLink>; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Prior+TW%22">Prior TW</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Döhner+K%22">Döhner K</searchLink>; Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Marcucci+G%22">Marcucci G</searchLink>; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Voso+MT%22">Voso MT</searchLink>; Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Klisovic+RB%22">Klisovic RB</searchLink>; Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Galinsky+I%22">Galinsky I</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+AH%22">Wei AH</searchLink>; Department of Clinical Haematology, The Alfred Hospital and Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Sierra+J%22">Sierra J</searchLink>; Hematology Department, Hospital de la Santa Creu i Sant Pau, IIB Sant Pau and Jose Carreras Leukemia Research Institute, Autonomous University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+MA%22">Sanz MA</searchLink>; Department of Hematology, Hospital Universitario y Politécnico La Fe and Department of Medicine, University of Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Brandwein+JM%22">Brandwein JM</searchLink>; Department of Medicine, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22de+Witte+T%22">de Witte T</searchLink>; Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Niederwieser+D%22">Niederwieser D</searchLink>; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Appelbaum+FR%22">Appelbaum FR</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Medeiros+BC%22">Medeiros BC</searchLink>; Division of Hematology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tallman+MS%22">Tallman MS</searchLink>; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Krauter+J%22">Krauter J</searchLink>; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schlenk+RF%22">Schlenk RF</searchLink>; Department of Internal Medicine III, University of Ulm, Ulm, Germany.; NCT Trial Center, National Center of Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ganser+A%22">Ganser A</searchLink>; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Serve+H%22">Serve H</searchLink>; Department of Medicine II, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt/Main, Germany.<br /><searchLink fieldCode="AU" term="%22Ehninger+G%22">Ehninger G</searchLink>; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Amadori+S%22">Amadori S</searchLink>; Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gathmann+I%22">Gathmann I</searchLink>; Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Döhner+H%22">Döhner H</searchLink>; Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Stone+RM%22">Stone RM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2021 Sep; Vol. 35 (9), pp. 2539-2551. <i>Date of Electronic Publication: </i>2021 Mar 02.
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