Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.
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| Title: | Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes. |
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| Authors: | Boyd MM; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, USA., Litscher SJ; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, USA., Seitz LL; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, USA., Messing A; Waisman Center, University of Wisconsin-Madison, Madison, USA.; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, USA., Hagemann TL; Waisman Center, University of Wisconsin-Madison, Madison, USA., Collier LS; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, USA. lcollier@wisc.edu. |
| Source: | Journal of neuroinflammation [J Neuroinflammation] 2021 Mar 08; Vol. 18 (1), pp. 67. Date of Electronic Publication: 2021 Mar 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1742-2094 |
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| DOI: | 10.1186/s12974-021-02118-x |
