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Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.

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Title: Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
Authors: Mahadevan NR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Knelson EH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Wolff JO; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Vajdi A; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts., Saigí M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Campisi M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy., Hong D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Thai TC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Piel B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Han S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Reinhold BB; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Duke-Cohan JS; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Poitras MJ; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts., Taus LJ; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Lizotte PH; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Portell A; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Quadros V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Santucci AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Murayama T; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Cañadas I; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Kitajima S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Akitsu A; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Fridrikh M; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Watanabe H; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gokhale PC; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts., Paweletz CP; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Awad MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Lako A; Translational Pathology, Bristol Myers Squibb, Trenton, New Jersey., Wang XT; Translational Pathology, Bristol Myers Squibb, Trenton, New Jersey., Chen B; Translational Pathology, Bristol Myers Squibb, Trenton, New Jersey., Hong F; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Sholl LM; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts., Pfaff K; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Jänne PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gjini E; Translational Pathology, Bristol Myers Squibb, Trenton, New Jersey., Edwards R; Translational Pathology, Bristol Myers Squibb, Trenton, New Jersey., Rodig S; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Oser MG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. david_barbie@dfci.harvard.edu matthew_oser@dfci.harvard.edu., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. david_barbie@dfci.harvard.edu matthew_oser@dfci.harvard.edu.
Source: Cancer discovery [Cancer Discov] 2021 Aug; Vol. 11 (8), pp. 1952-1969. Date of Electronic Publication: 2021 Mar 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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  Data: Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
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Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Hong+D%22">Hong D</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Thai+TC%22">Thai TC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Piel+B%22">Piel B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Reinhold+BB%22">Reinhold BB</searchLink>; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Duke-Cohan+JS%22">Duke-Cohan JS</searchLink>; 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Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fridrikh+M%22">Fridrikh M</searchLink>; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.<br /><searchLink fieldCode="AU" term="%22Watanabe+H%22">Watanabe H</searchLink>; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.<br /><searchLink fieldCode="AU" term="%22Reardon+B%22">Reardon B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gokhale+PC%22">Gokhale PC</searchLink>; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; 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