The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
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| Title: | The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo. |
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| Authors: | Read C; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Nyimanu D; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Yang P; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Kuc RE; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Williams TL; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Fitzpatrick CM; School of Chemistry and Astbury Centre for Structural Biology, University of Leeds, Leeds, United Kingdom., Foster R; School of Chemistry and Astbury Centre for Structural Biology, University of Leeds, Leeds, United Kingdom., Glen RC; Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Cambridge, United Kingdom.; Division of Systems Medicine, Department of Metabolism Digestion and Reproduction, Imperial College London, London, United Kingdom., Maguire JJ; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Davenport AP; Department of Medicine, Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2021 Jan 21; Vol. 11, pp. 588669. Date of Electronic Publication: 2021 Jan 21 (Print Publication: 2020). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2020.588669 |
