Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.

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Title: Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
Authors: Ravindra NG; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America., Alfajaro MM; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Gasque V; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.; Universite Claude Bernard Lyon 1, Faculte de Medecine Lyon Est, Lyon, France.; Department de Bioinformatique, Univ Evry, Universite Paris-Saclay, Paris, France., Huston NC; Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut, United States of America., Wan H; Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, Connecticut, United States of America., Szigeti-Buck K; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Yasumoto Y; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Greaney AM; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America., Habet V; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America., Chow RD; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America., Chen JS; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wei J; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Filler RB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wang B; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wang G; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut, United States of America., Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.; Department of Anesthesiology, Yale University, New Haven, Connecticut, United States of America., Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America., Eisenbarth SC; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Chen S; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America., Williams A; The Jackson Laboratory, Farmington, Connecticut, United States of America., Iwasaki A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., Horvath TL; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Foxman EF; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Pierce RW; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America., Pyle AM; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., van Dijk D; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America., Wilen CB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.
Source: PLoS biology [PLoS Biol] 2021 Mar 17; Vol. 19 (3), pp. e3001143. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-7885
DOI:10.1371/journal.pbio.3001143