Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
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| Title: | Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. |
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| Authors: | Ravindra NG; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America., Alfajaro MM; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Gasque V; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.; Universite Claude Bernard Lyon 1, Faculte de Medecine Lyon Est, Lyon, France.; Department de Bioinformatique, Univ Evry, Universite Paris-Saclay, Paris, France., Huston NC; Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut, United States of America., Wan H; Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, Connecticut, United States of America., Szigeti-Buck K; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Yasumoto Y; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Greaney AM; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America., Habet V; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America., Chow RD; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America., Chen JS; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wei J; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Filler RB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wang B; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Wang G; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut, United States of America., Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.; Department of Anesthesiology, Yale University, New Haven, Connecticut, United States of America., Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America., Eisenbarth SC; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Chen S; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America., Williams A; The Jackson Laboratory, Farmington, Connecticut, United States of America., Iwasaki A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., Horvath TL; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America., Foxman EF; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America., Pierce RW; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America., Pyle AM; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America., van Dijk D; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America., Wilen CB; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America. |
| Source: | PLoS biology [PLoS Biol] 2021 Mar 17; Vol. 19 (3), pp. e3001143. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 33730024 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ravindra+NG%22">Ravindra NG</searchLink>; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Alfajaro+MM%22">Alfajaro MM</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Gasque+V%22">Gasque V</searchLink>; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.; Universite Claude Bernard Lyon 1, Faculte de Medecine Lyon Est, Lyon, France.; Department de Bioinformatique, Univ Evry, Universite Paris-Saclay, Paris, France.<br /><searchLink fieldCode="AU" term="%22Huston+NC%22">Huston NC</searchLink>; Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Wan+H%22">Wan H</searchLink>; Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Szigeti-Buck+K%22">Szigeti-Buck K</searchLink>; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.<br /><searchLink fieldCode="AU" term="%22Yasumoto+Y%22">Yasumoto Y</searchLink>; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.<br /><searchLink fieldCode="AU" term="%22Greaney+AM%22">Greaney AM</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Habet+V%22">Habet V</searchLink>; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Chow+RD%22">Chow RD</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Chen+JS%22">Chen JS</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Filler+RB%22">Filler RB</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Niklason+LE%22">Niklason LE</searchLink>; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, United States of America.; Department of Anesthesiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Montgomery+RR%22">Montgomery RR</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Eisenbarth+SC%22">Eisenbarth SC</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; The Jackson Laboratory, Farmington, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Iwasaki+A%22">Iwasaki A</searchLink>; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Horvath+TL%22">Horvath TL</searchLink>; Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United of States of America.<br /><searchLink fieldCode="AU" term="%22Foxman+EF%22">Foxman EF</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Pierce+RW%22">Pierce RW</searchLink>; Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Pyle+AM%22">Pyle AM</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22van+Dijk+D%22">van Dijk D</searchLink>; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School Medicine, New Haven, Connecticut, United States of America.; Department of Computer Science, Yale University, New Haven, Connecticut, United States of America.<br /><searchLink fieldCode="AU" term="%22Wilen+CB%22">Wilen CB</searchLink>; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2021 Mar 17; Vol. 19 (3), pp. e3001143. <i>Date of Electronic Publication: </i>2021 Mar 17 (<i>Print Publication: </i>2021). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101183755 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-7885 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215449173%22">15449173 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Biol <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pbio.3001143 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e3001143 Titles: – TitleFull: Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ravindra NG – PersonEntity: Name: NameFull: Alfajaro MM – PersonEntity: Name: NameFull: Gasque V – PersonEntity: Name: NameFull: Huston NC – PersonEntity: Name: NameFull: Wan H – PersonEntity: Name: NameFull: Szigeti-Buck K – PersonEntity: Name: NameFull: Yasumoto Y – PersonEntity: Name: NameFull: Greaney AM – PersonEntity: Name: NameFull: Habet V – PersonEntity: Name: NameFull: Chow RD – PersonEntity: Name: NameFull: Chen JS – PersonEntity: Name: NameFull: Wei J – PersonEntity: Name: NameFull: Filler RB – PersonEntity: Name: NameFull: Wang B – PersonEntity: Name: NameFull: Wang G – PersonEntity: Name: NameFull: Niklason LE – PersonEntity: Name: NameFull: Montgomery RR – PersonEntity: Name: NameFull: Eisenbarth SC – PersonEntity: Name: NameFull: Chen S – PersonEntity: Name: NameFull: Williams A – PersonEntity: Name: NameFull: Iwasaki A – PersonEntity: Name: NameFull: Horvath TL – PersonEntity: Name: NameFull: Foxman EF – PersonEntity: Name: NameFull: Pierce RW – PersonEntity: Name: NameFull: Pyle AM – PersonEntity: Name: NameFull: van Dijk D – PersonEntity: Name: NameFull: Wilen CB IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 03 Text: 2021 Mar 17 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1545-7885 Numbering: – Type: volume Value: 19 – Type: issue Value: 3 Titles: – TitleFull: PLoS biology Type: main |
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