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Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer.

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Title: Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer.
Authors: Graham LS; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., True LD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Gulati R; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Schade GR; Department of Urology, University of Washington, Seattle, Washington, USA., Wright J; Department of Urology, University of Washington, Seattle, Washington, USA., Grivas P; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Yezefski T; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Nega K; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA., Alexander K; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Hou WM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Yu EY; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Montgomery B; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA., Mostaghel EA; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA., Matsumoto AA; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA., Marck B; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA., Sharifi N; Genitourinary Malignancies Research Center, Cleveland Clinic, Cleveland, Ohio, USA., Ellis WJ; Department of Urology, University of Washington, Seattle, Washington, USA., Reder NP; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Department of Mechanical Engineering, University of Washington, Seattle, Washington, USA., Lin DW; Department of Urology, University of Washington, Seattle, Washington, USA., Nelson PS; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Schweizer MT; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Source: The Prostate [Prostate] 2021 May; Vol. 81 (7), pp. 418-426. Date of Electronic Publication: 2021 Mar 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8101368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0045 (Electronic) Linking ISSN: 02704137 NLM ISO Abbreviation: Prostate Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer.
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  Data: <searchLink fieldCode="AU" term="%22Graham+LS%22">Graham LS</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22True+LD%22">True LD</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Gulati+R%22">Gulati R</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Schade+GR%22">Schade GR</searchLink>; Department of Urology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wright+J%22">Wright J</searchLink>; Department of Urology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Grivas+P%22">Grivas P</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Yezefski+T%22">Yezefski T</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Nega+K%22">Nega K</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+K%22">Alexander K</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Hou+WM%22">Hou WM</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Yu+EY%22">Yu EY</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Montgomery+B%22">Montgomery B</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Mostaghel+EA%22">Mostaghel EA</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Matsumoto+AA%22">Matsumoto AA</searchLink>; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Marck+B%22">Marck B</searchLink>; Geriatric Research Education and Clinical Care, VA Puget Sound Health Care System, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Sharifi+N%22">Sharifi N</searchLink>; Genitourinary Malignancies Research Center, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Ellis+WJ%22">Ellis WJ</searchLink>; Department of Urology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Reder+NP%22">Reder NP</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Department of Mechanical Engineering, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Lin+DW%22">Lin DW</searchLink>; Department of Urology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+PS%22">Nelson PS</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Schweizer+MT%22">Schweizer MT</searchLink>; Division of Oncology, Department of Medicine, University of Washington, Seattle, Washington, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
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  Data: <searchLink fieldCode="JN" term="%228101368%22">The Prostate</searchLink> [Prostate] 2021 May; Vol. 81 (7), pp. 418-426. <i>Date of Electronic Publication: </i>2021 Mar 23.
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