NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.

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Title: NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.
Authors: Mahling R; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Hovey L; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Isbell HM; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Marx DC; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Miller MS; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Kilpatrick AM; Department of Physics and Astronomy, Drake University, Des Moines, IA 50311-4516, USA., Weaver LD; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Yoder JB; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Kim EH; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Andresen CNJ; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Li S; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA., Shea MA; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA. Electronic address: madeline-shea@uiowa.edu.
Source: Structure (London, England : 1993) [Structure] 2021 Dec 02; Vol. 29 (12), pp. 1339-1356.e7. Date of Electronic Publication: 2021 Mar 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-4186
DOI:10.1016/j.str.2021.03.002