Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
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| Title: | Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling. |
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| Authors: | Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Post JB; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Laskaris D; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., van Ineveld RL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Kersten S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Bertotti A; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Sassi F; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy., Sipieter F; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris, France., Cappe B; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Mertens S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Boj SF; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Vries RGJ; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Rehmann H; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Vandenabeele P; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Riquet FB; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; University of Lille, Villeneuve d'Ascq, France., Trusolino L; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Bos JL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.; Oncode Institute, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl. |
| Source: | Nature cell biology [Nat Cell Biol] 2021 Apr; Vol. 23 (4), pp. 377-390. Date of Electronic Publication: 2021 Apr 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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